126 Free radicals and fast action to counteract oxidative damage in skin cells

نویسندگان

چکیده

Oxidative free radicals are one of the most toxic molecules produced in our body. damage accumulates over time, accelerates aging, and contributes to many age-related diseases such as cancer, heart disease Alzheimer’s disease. Our skin is directly exposed damaging environmental factors UV light pollution, which trigger production (FR). Combined with reactive oxygen species formed by skin’s own metabolism, these can overwhelm natural antioxidant defenses, especially ages defenses weakened. FR attack structural via oxidation 1) proteins, resulting an accumulation dysfunctional 2) lipids, impaired barrier cell membranes, 3) DNA, strand breaks DNA-protein crosslinks. In addition, activate mechanisms, collagen degradation collagenases increased inflammation, accelerated aging. Recently, a new source has been identified: blue light. Although from sunlight beneficial synchronize circadian rhythm daytime, it also generating FR. Skin’s exposure this continues at night LEDs for interior lighting devices. Nighttime causing desynchronization loss repair night, we have previously shown. We show that generates rapid rise level cells. Since highly reactive, essential act quickly fight them two actions: minimize their eliminate those generated. Therefore, developed exclusive lavender extract, helps FR, exposure. This technology cells defend against oxidative damage, healthier

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2022

ISSN: ['1523-1747', '0022-202X']

DOI: https://doi.org/10.1016/j.jid.2022.05.132